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Posts Tagged ‘Mechanism Of Action’

Viagra and other ED treatments

Saturday, April 17th, 2010

Erectile dysfunction is not a rare condition. The majority of men have erection problems sooner or later during their lives. The most important thing here is not to panic and seek for professional help as soon as you feel it has become a permanent issue. And by professional help we mean speaking to your physician, not seeking alternative remedies that promise impressive results but never deliver them. Why would you do that when there are numerous certified healthcare ways to treat erectile dysfunction of various degrees of severity?

Want to learn more about erectile dysfunction treatment options? No problem:

Psychological therapy

Doctors say that 9 out of 10 cases of male impotence have psychological causes. These causes may vary from simple stress to depression, fatigue, relationship problems or even mental illnesses. Neutralizing these elements usually helps restore sexual problems in a healthy fashion. An experienced therapist is able to put a man back on track even during a single session of behavior or group therapy. And sometimes just speaking things out helps people a lot.

Vacuum pumps

Vacuum pumps have been around for decades and are widely available in shops all over the world. Their mechanism of action is very simple: a plastic cylinder is for inserting the penis in, then using special seals and a valve mechanism the air from the cylinder is sucked out and thus vacuum is created. Vacuum around the penis stimulates the blood flow and results in a stronger more durable erection.

Medications

This type of ED treatments has seen a substantial growth over the last ten years. The introduction of Viagra has shown that it’s possible to overcome erectile dysfunction no matter how severe it may be. Soon other drugs have followed as well as generic Viagra variations from foreign manufacturers. Today millions of men buy Viagra and other similar drugs online making it a huge international market that is constantly growing. These drugs work by stimulating the blood flow inside the penis, but unlike penis pumps they cause a chemical reaction rather than a physical process.

Hormonal treatment

In certain cases impotence can be caused by hormonal imbalance, especially low levels of male hormone – testosterone. Restoring the balance is most likely to eliminate erectile dysfunction, however you should never do it on your own. First you have to run through different tests in order to define the problem and then take hormonal treatment under a strict supervision of your physician. Hormones are very dangerous to toy around with so take full responsibility before starting a course of hormonal treatment.

Prosthesis

This is the last resort for impotence treatment when all other methods have failed. There are different types and designs of implants that can be embedded into the penile shaft to allow the patient having sex. Some are semi-rigid others have special pumps that simulate the process of erection when needed. But always remember that if there’s a hope to treat the problem in a less implicative way you should try it first before going with an implant.

Surgery

Sometimes the physiological aspect of the penis can be the cause for erectile dysfunction. If a patient has certain abnormalities in the shape or structure of the penis this might be the factor causing the problem. In most cases these factors can be eliminated through surgery. Of course, a thorough medical examination before surgery is a must!

Dissociative (Conversion) Disorders

Sunday, August 30th, 2009


ciative (Conversion) Disorders

 

v Introduction and Definitions:

These terms replaced the old concept of hysteria (moving womb). However the term is still used until today even by clinician. It is best avoided as it creates clinical confusion and miscommunication.

The concept is that symptoms of physical illness or certain kind of mental illness have occurred in the absence of physical pathology with which they are normally associated and that the symptoms have been produced unconsciously.

The ICD 10 use the term interchangeably while the DSM-IV uses conversion for physical symptoms and dissociative for mental symptoms.

In the next sections the terms will be used interchangeably (ICD 10) for simplicity

Dissociative disorders can occur as primary disorder or as a feature of another psychiatric (e.g. depression) or organic disorder (temporal lobe epilepsy).

v Underlying “Mechanism of Action”:

The psychoanalytical explanation still offers the most plausible explanation for the occurrence of the symptoms of the disorder.

Although the symptoms are not produced deliberately, they present the patients ideas about the illness (i.e. from a personal experience or relative experience)

The symptoms usually confer some advantage to the patient:

Primary gain: exclusion from consciousness of anxiety due to psychological conflict. Repression of the i.d. Secondary gain: visible gain such as paralysis in the hand of a person taking care of an elderly. Secondary gain is extremely important to establish diagnoses and it should be reconsidered if it is absent. v Epidemiology:

Prevalence 3-6/1000 .F>M. very rare after 40 (suspect organicity)

v Aetiology:

  

•1.      Genetic: not very strong evidence although relatives have slightly higher rate. Twin studies do not support a strong genetic etiology. However somatization appears to be higher in relatives of patient with dissociation.

•2.      Organic: Some organic diseases can present with dissociation, especially if the CNS is involved (left side more than right). Recently huge interest and studies focus on the “organic” factors and possible neurological mechanism.

•3.      Psychological: Generally accepted that this is the immediate cause. The essential feature seems to be the capacity to dissociate i.e disconnects one aspect of psychological function from the rest when the person is subjected to severely stressful events.

•4.      Cultural: there has been decrease over the last decades especially in developed countries. Support for the role of social and cultural factors comes from studies showing that dissociative disorders are common among people from rural areas and lower socioeconomic class.

•5.      Personality:  more common in immature personalities and in personality disorders in general.

v Examples of Dissociative (conversion) Disorders:

-Dissociative Amnesia:

Sudden onset. A Person unable to recall long periods of life and may deny any knowledge of their previous life or personal identity.  Some have concurrent organic disease (e.g.  Epilepsy, MS or head injury), these patients with organic disorders may have similar symptoms and may be as suggestible as those without it.

-Dissociative Fugue:

Often occurs after severe stress. There is a loss of memory and wandering away from usual surrounding. When found the individual usually deny all memory of their whereabouts and may deny knowledge of personal identity. Fugue also occurs in epilepsy, severe depression and alcoholism. It may be associated with suicide attempts. Many give a history of severely disturbed relationship with their parents in childhood and others are habitual liars.

-Dissociative Stupor:

The patient is motionless and mute, not responding to stimulation, but aware of their surroundings. It is rare, but excludes schizophrenia, depression, mania and organic brain disorder.

-Ganser’s Syndrome:

Rare, commoner in prisoner, exclude psychosis (functional or organic) consist of four features:

1. Giving ‘approximate answers’ to questions of intellectual function (e.g. 2+2= 5) 2. Psychogenic physical symptoms 3. Hallucinations (? Pseudo hallucinations) usually visual and elaborate. 4. Apparent clouding of consciousness.

-Dissociative Identity Disorder (Multiple Personality Disorder):

Sudden alteration between two patterns of behavior each of which is forgotten by the patient when the other is present. Rare. Many report physical or sexual abuse (up to 95%). Patient often meet the criteria for other diagnoses especially antisocial personality disorders and drug abuse; they also have symptoms of anxiety and depression. Very suggestible.

-Dissociative Trance (Trance and Possession):

Temporary loss of the sense of personal identity and full awareness of the present surrounding. The person acting as if taken over by another personality for a brief period (e.g. religious ritual induced).

-Conversion Disorder:

Psychological cause leading to symptoms or deficit involving voluntary motor or sensory function. Common among people attending doctors. The pattern of symptoms reflects patients’ knowledge and sophistication and influenced by cultural and social factors.

With Motor symptoms:

Limb paralysis (psychogenic paralysis)ànot corresponding to nerves distribution, flexion and extension working simultaneously, wasting is absent. Psychogenic disorder of gait (e.g. astasia-abasia) Psychogenic tremor Globus hysterics

 

With Sensory symptoms:

Anesthesia Psychogenic blindness, deafness

With seizures and convulsions (Pseudo fits)

Distinguish from epilepsy in three ways:

-Does not become unconscious

-No stereotyped movement, incontinence, tongue bite, cyanosis or injury

-EEG normal.

-Interesting Related Syndrome!

Epidemic Hysteria: A dissociative disorder which spread within a group of people as an epidemic, this spread often happens in closed group of young women e.g. schools, nurses home, college resident (e.g. DMC!). Typically the epidemic starts in someone who is highly suggestible, histrionic (centre of attention) or psychotic (rare, refer to previous lectures; shared delusions).

v Differential Diagnoses:

Three ways in which physical disease may be wrongly diagnosed as a dissociative disorder.

1. Symptoms may be of physical disease which has not been discovered (e.g. brain CA) 2. Undiscovered brain disease may ‘release’ hysterical symptoms (e.g. TLE) 3. Anxiety caused by the awareness of the early symptoms of physical disease may act as a non-specific stimulus which provokes additional dissociative symptoms such as fugue.

Examples of differential diagnoses:

Organic disease of the CNS Parietal complex seizures Histrionic personality(under stress) Malingering.

To minimize error in diagnoses:

1. Usually does not appear after 40 2. Provoked by stress 3. Secondary gain 4. Belle indifference (hysterical indifference): less distress than would be expected of someone with the presenting symptoms. v Prognosis:

Most recover quickly but if longer than one year becomes difficult and last for several years.

v Treatment: Resolve stressful circumstances Suggestion Do not encourage behavior Abreaction in extreme cases using hypnoses or IV barbiturate

Reference:

1. Boyle D, Davies S. Psychiatry, Mosby’s crash course 2002.

2. Steple D. Oxford 2.Handbook of Psychiatry, Oxford University Press, 2006



Prof. Saoud Al Mualla (M.B, MSC, M.D, Dip, MRCPsych)